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Image Search Results
Journal: Frontiers in Microbiology
Article Title: Continuous Subcutaneous Delivery of Proline-Rich Antimicrobial Peptide Api137 Provides Superior Efficacy to Intravenous Administration in a Mouse Infection Model
doi: 10.3389/fmicb.2019.02283
Figure Lengend Snippet: Comparison of predicted Api137 plasma concentration curves for multiple iv ( A , full line and diamonds) and sc ( B , dashed line and diamonds) against measured plasma concentration after continuous sc infusion (red line and triangles). The prediction assumes multiple injections every 30 minutes corresponding to a total hourly dose of 20 mg/kg comparable to 19.2 mg/kg delivered hourly by the pump. For calculation of the area under the curve (AUC) with GraphPad Prism 5.02, data points within the period of constant plasma levels (6–20 h post implantation) were included for continuous sc infusion (AUC = 89 μg × min/mL). The AUC for 10 mg/kg q30 min iv and sc were predicted for the same period with 92 and 7 μg × min/mL, respectively.
Article Snippet: The log-rank (Mantel-Cox) test was used for comparison of the survival curves and dose-response curves were fitted with the “dose-response log(inhibitor) vs. normalized response – variable slope” function with “least squares fit” using
Techniques: Concentration Assay